Banca de QUALIFICAÇÃO: DANIEL CAVALCANTE DE OLIVEIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : DANIEL CAVALCANTE DE OLIVEIRA
DATE: 03/04/2024
TIME: 14:00
LOCAL: Sala 206 do Bloco Zeta do Campus de São Bernardo do Campo da Universidade Federal do ABC
TITLE:

Development of a 3D-Printed Prototype Bioabsorbable Cardiovascular Stent for Pediatric Aortic Coarctation

PAGES: 75
BIG AREA: Engenharias
AREA: Engenharia Biomédica
SUBÁREA: Engenharia Médica
SPECIALTY: Biomateriais e Materiais Biocompatíveis
SUMMARY:

The human heart functions as a crucial organ, serving as the primary pump to ensure continuous blood flow in the body. However, genetic factors can lead to congenital heart defects, with aortic coarctation being a notable example. Aortic coarctation affects 0.04% of the global population and is responsible for around 10% of congenital heart disease cases in adults. The pursuit of treating aortic coarctation and other cardiovascular diseases has driven the medical community to develop innovative therapies. The objective of this dissertation is the development of a 3D-printed bioabsorbable stent using Poly(L-Lactic Acid) (PLA), the most commonly used polymer for the production of bioabsorbable stents to treat Pediatric Aortic Coarctation. PLA both in its raw form and printed prototypes was characterized in terms of Chemical (FTIR), Thermal (TGA and DSC), and Mechanical Performance (Tensile strength, Linear Recoil, and 3-point bending) according to ASTM Standards. Stent geometry was created using in-house developed software and submitted this geometry to Finite Element Method analysis to determine the optimal structure. Results showed that the PLA both raw and printed prototypes had no difference chemically and thermally. Tensile testing pointed to the 45o angle to be optimal in printing our prototypes. Finite Element Analysis showed von Mises stresses above the yield strength of PLA (≈ 10MP a) and below the mean rupture stress (≈ 50MP a). Linear Recoil averaged at 31.8% on par with other studies and 3-point bending showed good reproducibility and deflection up to 2 mm. The results of these tests support the conclusion that rapid balloon expansion bioabsorbable stents made from PLA hold promise as a viable treatment option for pediatric aortic coarctation.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1760474 - PATRICIA APARECIDA DA ANA
Membro Titular - Examinador(a) Externo ao Programa - 1188948 - JOAO LAMEU DA SILVA JUNIOR
Membro Titular - Examinador(a) Externo à Instituição - ARON JOSE PAZIN DE ANDRADE - IDPC
Membro Suplente - Examinador(a) Interno ao Programa - 2090031 - ILKA TIEMY KATO PRATES
Membro Suplente - Examinador(a) Externo ao Programa - 2357820 - ANDERSON GABRIEL SANTIAGO CRAVO
Membro Suplente - Examinador(a) Externo à Instituição - EDUARDO GUY PERPÉTUO BOCK - IFSP