Use of photodynamic therapy to prevent complications in patients with Covid-19
Considering the stage that the new coronavirus disease has reached in Brazil and relating to the capacity of the Brazilian health system to treat affected patients, it was still necessary to adopt measures that minimized the symptoms of the disease or prevented its worsening. . In this context, photodynamic therapy (PDT) could have been a viable, non-invasive and low-cost alternative to inactivate the virus found in the oral and nasal cavities, given its proven effectiveness in generating species reactive oxygen sources that promote the death of bacteria, fungi and viruses. Thus, the present study sought to evaluate the effects of oral and nasal application of PDT in patients diagnosed with coronavirus and under hospitalization, seeking to prove whether such a strategy could be effective in reducing symptoms and, consequently, the length of stay for these patients. To this end, after a partnership with the General Hospital of São Caetano do Sul, 84 adult patients diagnosed positive for coronavirus were selected. PDT was performed by applying 200 µM methylene blue to the oral and nasal cavities through mouthwash and suction, respectively, and, after 5 minutes, irradiation was carried out with a red laser (l = 660 nm and power of 100 mW) for 12 minutes in each well. Patients were assessed by monitoring fever and other symptoms, as well as associated PCR laboratory tests (SWAB NASAL) for 30 days.