Banca de QUALIFICAÇÃO: MARCOS VINÍCIUS TEMPLE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARCOS VINÍCIUS TEMPLE
DATE: 13/11/2023
TIME: 14:00
LOCAL: https://conferenciaweb.rnp.br/sala/christiane-9
TITLE:

A model for pulmonary mechanics, gas exchange and respiratory control

PAGES: 65
BIG AREA: Engenharias
AREA: Engenharia Biomédica
SUBÁREA: Bioengenharia
SPECIALTY: Modelagem de Sistemas Biológicos
SUMMARY:

This work aimed at developing a model encompassing pulmonary mechanics, gas exchange, and part of the circulatory system, along with a control component for respiratory parameters in response to concentrations of the main gasses involved in respiration. The model was computationally implemented with the goal of being simple yet replicating the behavior observed in the literature, while also allowing parameter adjustments to simulate various conditions of activity and pathologies. The pulmonary mechanics model was based on the model proposed by Albanese et al. (2016) without significant changes. The electrical circuit analogous to the pneumatic system was solved to derive the differential equations describing the model, which were then solved using computational numerical integration methods. The compartmental gas exchange model was developed based on the works of Albuquerque Neto (2005), with a reduced number of compartments and an altered input parameter to accommodate a variable periodic air flow. The model considered only oxygen and carbon dioxide as gasses of interest for exchange. The respiratory control component involves a relationship between total ventilation and the partial pressure of carbon dioxide, incorporating the activity of chemoreceptors that regulate respiratory rhythm and the stimulation of respiratory muscles. The computational implementation was carried out using the Python programming language. The models were initially developed in isolation and later integrated, with the control component being added. The results presented by the pulmonary mechanics model were validated by comparison with the reference article for pressure, volume, and airflow curves, successfully reproducing its outcomes. The gas exchange model resulted in variations of partial pressures of oxygen and carbon dioxide in alveoli and pulmonary capillaries, and it was simulated under normal physiological conditions at rest. The obtained results closely matched literature observations, and given that data analysis was conducted in a transient regime, the degree of variation in values over the simulated time was satisfactory. The integrated system containing the control component was implemented after validating the isolated models and was simulated under the same conditions. Its results were similarly validated, and the impact of respiratory control was evaluated based on generated values for respiratory frequency and cardiac output, which fell within the expected range for the simulated activity level. Thus, it was concluded that despite the simplified aspects of the developed model, it was able to replicate expected behavior of the respiratory system, in terms of pulmonary mechanics, dynamics of the main gasses involved in respiration, and respiratory self-regulation.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1764675 - CHRISTIANE BERTACHINI LOMBELLO
Membro Titular - Examinador(a) Interno ao Programa - 1760474 - PATRICIA APARECIDA DA ANA
Membro Titular - Examinador(a) Externo à Instituição - CYRO ALBUQUERQUE NETO - FEI
Membro Suplente - Examinador(a) Interno ao Programa - 2390463 - PRISCYLA WALESKA TARGINO DE AZEVEDO SIMOES
Membro Suplente - Examinador(a) Interno ao Programa - 2090031 - ILKA TIEMY KATO PRATES
Membro Suplente - Examinador(a) Externo ao Programa - 1957691 - RONNY CALIXTO CARBONARI