Banca de QUALIFICAÇÃO: GABRIELLE LUANA JIMENEZ TEODORO NEPOMUCENO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : GABRIELLE LUANA JIMENEZ TEODORO NEPOMUCENO
DATA : 06/05/2025
HORA: 14:00
LOCAL: HÍBRIDA - S.A.
TÍTULO:

LIQUID OPTICAL BIOPSY USING FOURIER TRANSFORM INFRARED ABSORPTION TO IDENTIFY BIOMARKERS OF INFLAMMATION

PÁGINAS: 236
RESUMO:

In recent years, technologies that offer precision and fast in diagnosis and follow-up of treatment progress have aroused great interest, and minimally invasive procedures have been studied. Individuals affected by pathologies considered a global health problem, such as cancer, cardiovascular diseases, and autoimmune diseases, may be benefited by these technologies, contributing to early diagnosis. Understanding and knowing the biomolecular
basis, function, and homeostasis of the various systems that make up the human body could be the key to preventing and treating any pathology. In this work, we propose to investigate biofluid samples (saliva, blood serum, and urine) from patients with various diseases, as chronic hemodialysis, periodontitis patients with chronic kidney disease, peri-implantitis, e-cigarette and crack users, patients who venomous snakes, and patients with
oral cancer have bitten. The study aimed to find biomolecules that could be used as biomarkers in different inflammatory processes and to investigate the association between these pathologies and inflammation as a whole. Liquid biopsy samples were analyzed by Fourier Transform Infrared Absorption (FTIR). The spectra were processed and analyzed using R software with the ChemoSpec package. PCA, PLSDA, cross-validation, Vip scores,
and ROC curve analyses were also carried out for validation.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1676364 - JULIANA MARCHI
Membro Titular - Examinador(a) Interno ao Programa - 052.991.506-52 - JULIANA DA SILVA BERNARDES - UFABC
Membro Titular - Examinador(a) Externo à Instituição - PAULO HENRIQUE BRAZ DA SILVA - USP
Membro Titular - Examinador(a) Externo à Instituição - DÉBORA PALLOS
Membro Suplente - Examinador(a) Interno ao Programa - 2946001 - ANTONIO ALVARO RANHA NEVES
Membro Suplente - Examinador(a) Interno ao Programa - 1707133 - ISELI LOURENCO NANTES
Membro Suplente - Examinador(a) Externo à Instituição - JANETE DIAS ALMEIDA - UNESP