Banca de QUALIFICAÇÃO: ROBSON MARINO GARCIA SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ROBSON MARINO GARCIA SANTOS
DATA : 05/05/2021
HORA: 14:00
LOCAL: por participação remota
TÍTULO:

ADDITIVE MANUFACTURE FOR THE PRODUCTION OF BIORREACTORS:

Development of a bioreactor prototype to be produced through the additive manufacturing

PÁGINAS: 91
GRANDE ÁREA: Engenharias
ÁREA: Engenharia de Produção
SUBÁREA: Engenharia do Produto
ESPECIALIDADE: Desenvolvimento de Produto
RESUMO:

Severe bone tissue damage, which can lead to the need for base tissue replacement, is a problem that affects millions of people annually, and whose current techniques for treatment still have several limitations and problems. Searching for an alternative to traditional techniques, tissue engineering, a multidisciplinary area focused on the in vitro development of substitutes for human tissues, has been studying the cultivation and/or differentiation of the patient's own bone cells in porous support structures (scaffolds) tailored to meet the needs of patients. The culture of cells in these structures requires dynamic processes, to enable the development of larger tissues, due to the transport of nutrients and removal of debris from regions further away from the surface. For this purpose, bioreactors are used, equipment that usually have complex structures, difficult to manufacture, and that allow the control of physical, chemical and biological characteristics of the system. In order to simplify the development of these bioreactors, researchers have studied the application of Additive Manufacturing in their manufacture. Thus, this work aims, based on the analysis of how Additive Manufacturing has been approached in the scientific literature for the manufacture of bioreactors, mainly for the cultivation of bone cells, to propose a prototype of a bioreactor for the cultivation of these cells, to be validated by the simulation of the shear stress generated in a scaffold model inserted in the system, performed in the Flow Simulation tool of the Solidworks 2013 software, and compared with values from the literature. The results of the review indicate that this application of Additive Manufacturing is relatively new, and has become more relevant in the last decade, indicating that it is a promising topic, but studies on this topic are still scarce and diverse. All the analyzed variations of the developed prototype were able to generate shear stress values within the range identified in the literature as adequate. In addition, the proposed model is considerably different from the other models of bioreactors for bone tissues identified in the literature, having as main positive characteristics the modularity, practicality of use and having been thought to accommodate a range of variations in the shape and dimension of the scaffolds.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 2187277 - LEONARDO RIBEIRO RODRIGUES
Membro Titular - Examinador(a) Interno ao Programa - 2073298 - ERIK GUSTAVO DEL CONTE
Membro Titular - Examinador(a) Externo à Instituição - CECILIA AMELIA DE CARVALHO ZAVAGLIA - UNICAMP
Membro Suplente - Examinador(a) Interno ao Programa - 2403225 - UGO IBUSUKI
Membro Suplente - Examinador(a) Externo à Instituição - ANDRE LUIZ JARDINI MUNHOZ - UNICAMP