Structure and Function

The main objectives of this research line are:

1) Study of the molecular characteristics of the various biosystems formed by their basic structural components, that acquire hierarchical levels of organization and result in structural relationships and interactions in the same levels or between different levels.

2) Establish relationships between molecular characteristics and alterations in function, dynamics and interactions between its components or with the external environment, in the different studied biosystems (prokaryotes and eukaryotes)

Modeling and Technology

This research line applies to:

1) Multiparametric analyses utilizing computational models as tools capable of simulating molecular structures and intermolecular interactions, complementing experimental data obtained in the laboratory.

2) Development, characterization and evaluation of the possible therapeutic applicability of new technologies to diagnosis and treatment of human and/or veterinary pathologies.

Concentration Areas:

Biochemistry

Proteases/ Enzymology / Enzymatic inhibitors

(Dr. Sergio Daishi Sasaki, Dr. Luciano Puzer)

Copper biochemistry / Bioinorganics.

(Dr. Giselle Cerchiaro, Dr. Rodrigo Cunha)

Bioinformatics 

Computational biology / Molecular modeling.

(Dr. Antônio Sergio Kimus Braz, Dr. Ana Ligia Scott, Dr. Renato Ferreira de Freitas)

Cancer         

Molecular biology of cancer / Tumoral metabolism / Mechanisms of cell death / Antitumoral chemotherapy.

(Dr. Ana Carolina Santos de Souza Galvão, Dr. Tiago Rodrigues)

Immunology

Exhaustion mechanisms of immune system.

(Prof Vinicius de Andrade Oliveira)

Metabolism and Bioenergetics

Energy metabolism of central nervous system / Mitochondrial bioenergetics / Obesity / Muscular tissue / Adipose tissue.

(Dr. César Augusto João Ribeiro, Dr. Marcelo Augusto Christoffolete)

Molecular Biology

Molecular biology of microorganisms / Genomics / Molecular diagnosis / Molecular genetics.

(Dr. Luiz Roberto Nunes, Márcia Aparecida Sperança)

Neuroscience

Molecular and cellular aspects of neurodevelopment and neurodegeneration / Environmental factors impacting on Alzheimer’s disease.

(Dr. Alexandre Hiroaki Kihara, Dr. Maria Camila Almeida) 

Pathophysiology

Inflammatory cytokines on cardiac trophism / Pain and inflammation / Protease inhibitors applied to lung emphysema / Pathophysiology of inborn metabolic disorders.

(Dr. Marcela Sorelli Carneiro Ramos, Dr. Daniele Ribeiro de Araujo, Dr. Sergio Daishi Sasaki, Dr. César Augusto João Ribeiro)

Pharmacology

Nanomaterials that release nitric oxide for biomedical and agricultural applications / Systems for drugs and other bioactives release.

(Dr. Amedea Barozzi Seabra, Dr. Daniele Ribeiro de Araujo)

Virology

Mechanisms of viral replication and pathogenesis / Development of serological tests and vaccines.

(Dr. Maria Cristina Carlan da Silva, Dr. Helena Ruthner Batista, Dr. Márcia Aparecida Sperança)