Banca de QUALIFICAÇÃO: JOSE EDUARDO ULLOA ROJAS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOSE EDUARDO ULLOA ROJAS
DATE: 20/10/2022
TIME: 14:00
LOCAL: Modo remoto (meet.google.com/ifj-zuef-twm)
TITLE:

Silk fibroin/poly(vinyl alcohol) microneedles for singlet oxygen photosensitizer delivery system.

PAGES: 82
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Photodynamic therapy (PDT) is a medical treatment in which a combination of a photosensitizing drug and visible light produces highly cytotoxic reactive oxygen species (ROS) that leads to cell death. One of the main drawbacks of PDT for topical treatments is the limited skin penetration of some photosensitizers commonly used in this therapy. In this study, we propose the use of polymeric microneedles (MNs) prepared from silk fibroin and poly(vinyl alcohol) (PVA) to increase the penetration efficiency of porphyrin as possible applications in photodynamic therapy. The microneedle arrays were fabricated from mixtures in different proportions (1:0, 7:3, 1:1, 3:7, and 0:1) of silk fibroin and PVA solutions (7%); the polymer solutions were cast in polydimethylsiloxane (PDMS) molds and dried overnight. Patches containing grids of 10 × 10 microneedles with a square-based pyramidal shape were successfully produced through this approach. The polymer microneedle arrays showed good mechanical strength under compression force and sufficient insertion depth in both Parafilm M and excised porcine skin at different application forces (5, 20, 30, and 40 N) using a commercial applicator. We observe an increase in the cumulative permeation of 5-[4-(2-carboxyethanoyl) aminophenyl]-10,15,20-tris-(4-sulphonatophenyl) porphyrin trisodium through porcine skin treated with the polymer microneedles after 24 h. MNs may be a promising carrier for the transdermal delivery of photosensitizers for PDT, improving the permeation of photosensitizer molecules through the skin, thus improving the efficiency of this therapy for topical applications.

BANKING MEMBERS:
Presidente - Interno ao Programa - 052.991.506-52 - JULIANA DA SILVA BERNARDES - UFABC
Membro Titular - Examinador(a) Interno ao Programa - 1676364 - JULIANA MARCHI
Membro Titular - Examinador(a) Externo ao Programa - 2125782 - ANDREA CECILIA DORION RODAS
Membro Titular - Examinador(a) Externo ao Programa - 1544379 - ANDERSON ORZARI RIBEIRO
Membro Suplente - Examinador(a) Interno ao Programa - 1734908 - FABIO FURLAN FERREIRA
Membro Suplente - Examinador(a) Interno ao Programa - 1305186 - SERGIO BROCHSZTAIN
Membro Suplente - Examinador(a) Interno ao Programa - 1761120 - DANILO JUSTINO CARASTAN
Membro Suplente - Examinador(a) Externo ao Programa - 1762438 - JEAN JACQUES BONVENT