Hybrid magnetic and antinacterial nanoparticles: synthesis, characterization and applications
Recently, the preparation of hybrid nanostructured materials represents a promising strategy in the development of new platforms for obtaining versatile nanomaterials with different characteristics and functions, in a single nanostructure. Iron oxide (Fe3O4) superparamagnetic nanoparticles have received a high profile in recent years, thanks to the versatility of their biomedical applications such as diagnostics, magnetic resonance imaging, cancer treatment, controlled drug transport, among others. Similarly, silver nanoparticles (Ag) demonstrate potent antibacterial action and are used in the food, textile, perfumery, pharmaceutical and agricultural industries. In this context, the present project aims at the synthesis and characterization of Fe3O4 @ Ag nanoparticles, involving chemical and biogenic synthesis processes, which are: (i) superparamagnetic, and (ii) antibacterial. The application of the external magnetic field can also be used to remove these nanoparticles from the medium of interest, this action has implications for the reuse of these nanoparticles in biomedical applications, as well as their proper removal from the environment. In order to improve the antibacterial action of the nanoparticles, in addition to increasing their dispersion in aqueous medium and biocompatibility, the surface of the Fe3O4 @ Ag nanoparticles will be covered with chitosan, a biocompatible, biodegradable and antimicrobial polymer. In addition, the coating of the surface of the nanoparticles with chitosan allows the incorporation of nitric oxide donors, recognized for their antibacterial action. Therefore, the project includes the preparation of hybrid nanoparticles that are magnetic and antimicrobial, by chemical and biogenic methods, with great potential for use in biomedical applications.