Banca de QUALIFICAÇÃO: JOSÉ MATHEUS DE FREITAS COSTA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : JOSÉ MATHEUS DE FREITAS COSTA
DATA : 09/03/2020
HORA: 14:00
LOCAL: sala 301, 3º andar, Bloco B, Campus SA da Fundação Universidade Federal do ABC, localizada na Avenida dos Estados, 5001, Santa Terezinha, Santo André, SP
TÍTULO:

Synthesis and characterization of xanthene derivatives for application as photosensitizers in photodynamic therapy

PÁGINAS: 20
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Inorgânica
ESPECIALIDADE: Química Bio-Inorgânica
RESUMO:

Photodynamic therapy (PDT) is a type of therapeutic modality used to treat various types of cancer, including head and neck, and microbial infections. In general, Photodynamic Therapy involves three variants for its action: i) the application of an active principle, called photosensitizer (PS), ii) light and iii) oxygen present in the medium. The incidence of light promotes the excitation of the PS to an excited energetic state that, when transferring energy and / or electrons to the oxygen molecules around it, generates a complex mixture of reactive species, species that react with biomolecules causing irreparable cellular damage . In recent years, in order to increase the efficiency of PDT, studies have been carried out to develop new photosensitizing drugs, more selective, of non-prolonged photosensitivity, simplicity of formulation, favorable pharmacokinetics, ease of synthesis, low cost and non-toxic in absence of light. In this context, xanthenes are quite promising, as they are a class of compounds that absorb light in the visible region, are easily synthesized, have good biological compatibility and have a high rate of generation of reactive oxygen species after light absorption. This work presents the synthesis and characterization of new xanthene derivatives using synthetic routes adapted from the literature, promoting chemical modifications in xanthene precursors such as resorcinol and phthalic anhydride derivatives. Our results show the possibility of promoting structural changes that can enable greater interaction with the target cells, as well as improving the quantum yield of generating reactive oxygen species.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1544379 - ANDERSON ORZARI RIBEIRO
Membro Titular - Examinador(a) Interno ao Programa - 1600860 - ALVARO TAKEO OMORI
Membro Titular - Examinador(a) Interno ao Programa - 1623577 - JOAO HENRIQUE GHILARDI LAGO
Membro Suplente - Examinador(a) Interno ao Programa - 1939561 - FERNANDO HEERING BARTOLONI
Membro Suplente - Examinador(a) Interno ao Programa - 1544344 - VANI XAVIER DE OLIVEIRA JUNIOR