Banca de QUALIFICAÇÃO: RITA DE CÁSSIA CREMASCO ARANHA DÁRTORA
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.DISCENTE : RITA DE CÁSSIA CREMASCO ARANHA DÁRTORA
DATA : 05/02/2020
HORA: 13:30
LOCAL: sala 304, 3º andar, Bloco B, Campus SA da Fundação Universidade Federal do ABC, localizada na Avenida dos Estados, 5001, Santa Terezinha, Santo André, SP
TÍTULO:
RACEMIC SYNTHESIS OF METHOXYLATED CARAMBOXIN
PÁGINAS: 20
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:
Brazilian researchers isolated in 2013 the compound responsible for the possible neurotoxic effects caused by the ingestion of star fruit (Averrhoa carambola) - caramboxin. The neurotoxin structure contains a phenylalanine backbone and the absolute configuration of the α-amino acid carbon was only inferred by comparing the signal of the L-phenylalanine [α] D values and the compound in question. Chirality is closely related to the biological activity of the molecule, and therefore for further proof of its absolute configuration this project will focus on synthetic studies of this compound in racemic form. The proposed route for caramboxin synthesis involves 3,5-dimethoxybenzoic acid as a starting material, following another reaction of the product of this reaction undergoes insertion of the formyl group (-CHO) and consequent oxidation via Lindgren reaction as a key step of the synthetic route. If the results are satisfactory and the reaction yields, in the end the product obtained will hydrolyze to the methoxylated caramboxin and in racemic form.
MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1600860 - ALVARO TAKEO OMORI
Membro Titular - Examinador(a) Interno ao Programa - 1623577 - JOAO HENRIQUE GHILARDI LAGO
Membro Titular - Examinador(a) Externo à Instituição - LEANDRO HELGUEIRA DE ANDRADE - USP
Membro Suplente - Examinador(a) Interno ao Programa - 1766090 - MIRELA INES DE SAIRRE
Membro Suplente - Examinador(a) Externo ao Programa - 1909951 - ARTUR FRANZ KEPPLER