Banca de DEFESA: CARLA CRISTINA DECANDIO
Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.DISCENTE : CARLA CRISTINA DECANDIO
DATA : 19/07/2019
HORA: 13:30
LOCAL: sala 404, 4º andar, Bloco B, Campus SA da Fundação Universidade Federal do ABC, localizada na Avenida dos Estados, 5001, Santa Terezinha, Santo André, SP
TÍTULO:
Hybrid hydrogels PEG-biconjugated with silylated amyloidogenic peptide.
PÁGINAS: 90
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Físico-Química
ESPECIALIDADE: Química do Estado Condensado
RESUMO:
Hydrogels hybrid-peptide arrangements are a promising alternative for obtaining biocompatible structures at the nanoscopic scale. Several of combinations between different amino acids allows the construction of a vast number of supramolecular architectures with equally diverse physicochemical properties. Therefore, combining hybrid copolymers with biomolecules makes them interest for biomedical and biomaterials applications, such as tissue engineering and drug delivery systems. In this work a new class of hybrid hydrogels was obtained by the sol-gel process, based on a peptide-b-amyloid sequence composed exclusively by arginine, phenylalanine and glycine (Gly [Arg-Phe]4). This sequence wassynthesized and functionalized with alkoxysilanes, obtained by solid-phase strategies. Then, covalently bound to hybrid silylated PEG. 1H NMR, LC/MS and FTIR analysis were used providing synthesized molecules formation. Infrared data has given information of hybrid hydrogels, and also forms type b-sheet structures. Thermal analysis measurement provides us thermal stability of hydrogels, also corroborates with the structural FTIR data about their formation. Mechanical properties results showed elastic behavior, with storage moduli higher than loss moduli and 0,09 PPS sample showed thixotropic properties. SAXS measures provided information about system organization, demonstrating two distinct regimes. Corroborating with SAXS data electron microscopy and atomic force images revealed amorphous and fibrillar regimes depending on the peptide-silane concentration in the hydrogel matriz.
MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1544341 - WENDEL ANDRADE ALVES
Membro Titular - Examinador(a) Interno ao Programa - 1864481 - HUEDER PAULO MOISES DE OLIVEIRA
Membro Titular - Examinador(a) Externo ao Programa - 1675708 - DANIELE RIBEIRO DE ARAUJO
Membro Titular - Examinador(a) Externo ao Programa - 1669182 - JOSE FERNANDO QUEIRUGA REY
Membro Titular - Examinador(a) Externo à Instituição - ANAMARIA DIAS PEREIRA ALEXIOU - UPM
Membro Suplente - Examinador(a) Interno ao Programa - 1544379 - ANDERSON ORZARI RIBEIRO
Membro Suplente - Examinador(a) Externo ao Programa - 1763495 - WANIUS JOSE GARCIA DA SILVA
Membro Suplente - Examinador(a) Externo à Instituição - ELISABETH ANDREOLI DE OLIVEIRA - UNB