Banca de QUALIFICAÇÃO: FELIPE DA SILVA SALES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : FELIPE DA SILVA SALES
DATE: 03/02/2023
TIME: 13:00
LOCAL: https://conferenciaweb.rnp.br/webconf/felipe-336
TITLE:

TRITERPENES WITH ANTI-Trypanosoma cruzi ACTION FROM Vernonanthura polyanthes (Sprengel) Vega & Dematteis (ASTERACEAE)

PAGES: 52
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:

Ethnopharmacological knowledge, besides a cultural heritage of a people, is crucial
for phytochemicals, botanists and pharmacists to be able to seek and develop new
treatments and active principles with appreciable activity. In possession of popular
wisdom about the use of assa-peixe for the treatment of pain, inflammation and
respiratory tract disorders, with reviews in the literature and multidisciplinary work
with partners in botany and also pharmacy, work on the evaluation of the biological
activity of special metabolites of Vernonanthura polyanthes (Sprengel) Vega &
Dematteis (Asteraceae). The apolar extract was obtained by macerating the aerial
parts previously dried and ground in n-hexane, which was then subjected to
chromatographic fractionation in an open column using silica gel (70-230 mesh) as a
stationary phase with n-hexane : ethyl acetate as mobile phase in increasing polarity
gradient. Sixteen fractions (EHB) were obtained, which were analyzed by 1H and 13C
NMR and subsequently submitted to in vitro assays for anti-T. cruzi. From these
fractions EHB8~9 active against the parasite and also EHB5~6 stood out due to the
great similarity of the spectral profile. The compounds Lupeol, α-Amyrin, β-Amyrin
and ψ-Taraxasterol were identified in a mixture in EHB8~9 and their respective
acetylated derivatives in EHB5~6, structures were confirmed by GC-MS analysis.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1544365 - GISELLE CERCHIARO
Membro Titular - Examinador(a) Interno ao Programa - 3008569 - BRUNO GUZZO DA SILVA
Membro Titular - Examinador(a) Interno ao Programa - 1762430 - DALMO MANDELLI
Membro Suplente - Examinador(a) Interno ao Programa - 1844792 - AMEDEA BAROZZI SEABRA
Membro Suplente - Examinador(a) Interno ao Programa - 1623577 - JOAO HENRIQUE GHILARDI LAGO
Membro Suplente - Examinador(a) Externo ao Programa - 1544951 - ANA PAULA DE MATTOS AREAS DAU