Banca de QUALIFICAÇÃO: RAFAEL NUNES GOMES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RAFAEL NUNES GOMES
DATE: 12/12/2022
TIME: 13:00
LOCAL: Sala 406 do Bloco B do Campus de Santo André da Universidade Federal do ABC
TITLE:

Synthesis of new copper(II) complexes using natural products as ligands with antitumor action

PAGES: 20
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

Metal complexes are interesting for cancer treatment due to the unique properties of metals, including the redox potential, several possible coordination structures with different types of ligands, the most diverse geometries, and different reactivity with biomolecules. The discovery of cisplatin decades ago represented a significant advance in searching cancer therapies. From this, efforts were made to develop compounds with other structures and use other metallic centers. In this context, the present work seeks to synthesize new copper complexes with imine ligands from natural aldehydes, such as vanillin, cinnamaldehyde, and ethylvanillin. The ligands were obtained through the reaction of these aldehydes with the amines 1,3-Diaminopropane, 2,2-dimethyl-1,3-propanediamine, and 1,3-diamino-2-propanol and characterized by NMR, IR, and high-resolution mass spectrometry. The complexation reaction was carried out with copper(II) as perchlorate salt, and six imine copper complexes were obtained. The complexes were characterized using infrared and UV-vis spectroscopy, elemental analysis, mass spectrometry, and nuclear paramagnetic resonance. The cytotoxicity of the complexes was evaluated using the MTT assay on neuroblastoma cell lines: SH-SY5Y, CHP 212, and LN-18. The complexes presented a structure with a proportion of a ligand to a metallic center. The in vitro assays showed the cytotoxic potential of the complexes for the neuroblastoma cell lines, presenting IC50 values between 90 and 300µM. The newly synthesized copper imine complexes show toxicity against neuroblastoma tumor cells.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1544365 - GISELLE CERCHIARO
Membro Titular - Examinador(a) Interno ao Programa - 2351974 - JULIANA DOS SANTOS DE SOUZA
Membro Titular - Examinador(a) Externo à Instituição - LUIZ DUARTE RAMOS
Membro Suplente - Examinador(a) Interno ao Programa - 1623774 - KARINA PASSALACQUA MORELLI FRIN