Banca de DEFESA: JOSÉ MATHEUS DE FREITAS COSTA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOSÉ MATHEUS DE FREITAS COSTA
DATE: 15/12/2022
TIME: 14:00
LOCAL: Auditório 801 no 8º andar do Bloco B do Campus Santo André da Universidade Federal do ABC
TITLE:

Synthesis and characterization of xanthene derivatives for application as photosensitizers in photodynamic therapy

PAGES: 90
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:

Photodynamic therapy (PDT) is a type of therapeutic modality used in the treatment of various types of cancer, including head and neck, and microbial infections. In general terms, Photodynamic Therapy involves three variants for its action: i) the application of an active principle, called photosensitizer (PS), ii) Light and iii) oxygen present in the medium. The incidence of light promotes the excitation of the FS to an excited energetic state that, by transferring energy and/or electrons to the oxygen molecules around it, generates a complex mixture of reactive species, species that react with biomolecules causing irreparable cellular damage. Among the potential photosensitizers, the Xanthenes class stands out, a class of dye that presents a good yield of generation of reactive oxygen species under irradiation with adequate wavelength. Despite its proven efficiency as a photosensitizer, many studies are limited to describing the action of commercial xanthenes such as Fluorescein (FSC), Rose Bengal (RB), Erythrosine (ES) and Eosin (ESY), not having many advances related to other xanthenes with modifications in their structure. In this work we performed the synthesis of 16 xanthenes with the objective of studying their photophysical properties and applying them in PDT. The synthesized compounds were purified and characterized by NMR-1H and 13C techniques, of which we can mention the synthesis of Fluorescein, 3´,4´,5´,6´-tetrabromo-fluorescein, 3´,4´,5´, 6´-tetrachloro-fluorescein, 3´,4´,5´,6´-tetrafluor-fluorescein, 4´,5´, -dichloro-fluorescein, 4´(5´)-nitro-fluorescein, 2´(3´ )-nitro-fluorescein, 2,7-dicarboxy-fluorescein, dihydro-fluorescein, 4´(5´)-carboxy-fluorescein, 3´(4´)-tert-butyl-fluorescein, naphtha-fluorescein, and the ethyl esters , isopropyl, n-butyl and isobutyl of carboxy-fluorescein. The development of a methodology for separating the isomers of carboxy-fluorescein esters using the preparative HPLC system is highlighted.

BANKING MEMBERS:
Presidente - Interno ao Programa - 1544379 - ANDERSON ORZARI RIBEIRO
Membro Titular - Examinador(a) Interno ao Programa - 1544344 - VANI XAVIER DE OLIVEIRA JUNIOR
Membro Titular - Examinador(a) Interno ao Programa - 1544394 - PAULA HOMEM DE MELLO
Membro Titular - Examinador(a) Externo à Instituição - PAULO SERGIO CALEFI - IFSP
Membro Titular - Examinador(a) Externo à Instituição - JOSÉ AGUSTÍN QUINCOCES SUÁREZ - UNIAN-SP
Membro Suplente - Examinador(a) Interno ao Programa - 1600860 - ALVARO TAKEO OMORI
Membro Suplente - Examinador(a) Externo ao Programa - 1671688 - ANDRE SARTO POLO
Membro Suplente - Examinador(a) Externo à Instituição - PABLO JOSE GONÇALVES - UFG