Banca de QUALIFICAÇÃO: JOANA CLAUDIO PIERETTI

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOANA CLAUDIO PIERETTI
DATE: 07/11/2022
TIME: 13:30
LOCAL: Sala 406 do Bloco B do Campus de Santo André da Universidade Federal do ABC
TITLE:

Impact of nanoplatforms allied to nitric oxide and chemotherapeutics on cytotoxicity and sensitization of resistant tumor cells

PAGES: 25
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Físico-Química
SUMMARY:

Currently, cancer represents the second disease with the highest mortality rate worldwide, demonstrating challenges regarding the diagnosis and the treatment. In recent decades, cancer treatments have improved, but they still face difficulties related to high biodistribution, due to the non-specificity, and also the growing tumor resistance to these conventional treatments. In this scenario, nanotechnology has gained space in the field of medicine by enabling the design of materials that provide efficient, targeted applications with minimal side effects. This area has grown exponentially worldwide, with notable financial investment which have translated into the commercialization of more than 100 FDA approved products with applications in nanomedicine. Among several nanoparticles with applications in this area, porous nanoparticles, such as zinc oxides and silicon (ZnO and SiO2), consist of a potential strategy for an efficient delivery of drugs with reduced side effects. A few years ago, the use of nanotechnology in cancer was based only on a targeted treatment using drug-loaded nanoparticles. However, it has been increasing a simultaneous multi-drug delivery strategy, in order to sensitize tumor cells, especially cells resistant to current therapeutics. In this sense, a combination of chemotherapeutics with nanoparticles functionalized with S-nitrosochitosan, chemically modified chitosan polymer for nitric oxide (NO) release, consists of an innovative strategy that aims to sensitize tumor cells with low NO rates, potentializing the chemotherapy treatment. Thus, this project consists in the development of nanoparticles carrying chemotherapeutic agents functionalized with modified chitosan molecules, allowing the release of nitric oxide (NO), an endogenous signaling molecule, capable of sensitizing the tumor cells by several routes and, therefore, enabling a more effective treatment. Hybrid nanoparticles will be synthesized, functionalized and characterized by several techniques. In vitro antitumoral experiments will be carried out in order to investigate the potential and the different death pathways involved in the treatment employing the synthesized nanoparticles. Therefore, this project allows advances in the area of cancer nanomedicine combined with NO, generating scientific and technological contributions in the area of nanomaterials, NO, biology and medicine.

BANKING MEMBERS:
Presidente - Interno ao Programa - 1844792 - AMEDEA BAROZZI SEABRA
Membro Titular - Examinador(a) Interno ao Programa - 1544365 - GISELLE CERCHIARO
Membro Titular - Examinador(a) Externo ao Programa - 1768959 - FERNANDO CARLOS GIACOMELLI
Membro Suplente - Examinador(a) Interno ao Programa - 1623577 - JOAO HENRIQUE GHILARDI LAGO
Membro Suplente - Examinador(a) Externo ao Programa - 1672728 - ANA CAROLINA SANTOS DE SOUZA GALVAO