Banca de QUALIFICAÇÃO: MARINA DE MONROE GONÇALVES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : MARINA DE MONROE GONÇALVES
DATA : 29/04/2022
HORA: 14:00
LOCAL: on line
TÍTULO:

Anti-Trypanosoma cruzi activity of lignans isolated from the hexane extract of the branches of Piper truncatum Vell.

PÁGINAS: 20
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Química dos Produtos Naturais
RESUMO:

Neglected tropical diseases (NTDs) are a set of diseases caused by infectious agents or parasites, which affect more than 1 billion individuals. In Brazil, despite the existence of public policies aimed at overcoming NTDs, Chagas disease is still a public health issue. Chagas disease is a disease caused by the protozoan Trypanosoma cruzi that affects more than 6 million people, where only here in Brazil, 533 new cases were reported in 2020. Even causing more than 14 thousand deaths per year, the therapeutic arsenal – nifurtimox and benznidazole – have reduced action in the chronic phase of the disease and have several side effects. Within this context, even affecting a significant portion of the population, NTDs still have a disproportionately low development of new drugs. Thus, the systematic study of natural products is essential for the discovery of new drugs, where the Piper genus has great potential in view of the diversity of classes of special metabolites that it produces. The species Piper truncatum Vell. It is a shrub that can reach approximately 3 meters in height. It is a native species of the Atlantic Forest and can be found in all states of the Southeast region. Regarding the phytochemistry of the species, only the isolation of the furofuran lignan eudesmin is reported in the literature. The present work then describes the isolation of three new lignans in the species – hinokinin, sesamin and kobusin – which were isolated from several biomonitored chromatographic fractionations.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1623577 - JOAO HENRIQUE GHILARDI LAGO
Membro Titular - Examinador(a) Externo ao Programa - 3008569 - BRUNO GUZZO DA SILVA
Membro Titular - Examinador(a) Externo à Instituição - PATRÍCIA SARTORELLI - UNIFESP
Membro Suplente - Examinador(a) Interno ao Programa - 1544365 - GISELLE CERCHIARO