Banca de QUALIFICAÇÃO: RODRIGO CESAR BONINI

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : RODRIGO CESAR BONINI
DATE: 01/09/2023
TIME: 14:00
LOCAL: por participação remota em https://conferenciaweb.rnp.br/sala/david-41
TITLE:

Gene Networks Inference by Reinforcement Learning

PAGES: 50
BIG AREA: Ciências Exatas e da Terra
AREA: Ciência da Computação
SUBÁREA: Metodologia e Técnicas da Computação
SUMMARY:

Gene Regulatory Networks inference from gene expression data is an important problem in systems biology field, involving the estimation of gene-gene indirect dependencies and the regulatory functions among these interactions to provide a model that explains the gene expression dataset. The main goal is to comprehend the global molecular mechanisms underlying diseases for the development of medical treatments and drugs. However, such a problem is considered an open problem, since it is difficult to obtain a satisfactory estimation of the dependencies given a very limited number of samples subject to experimental noises. Many gene networks inference methods have been proposed in the literature, where some of them use heuristics or model based algorithms to find interesting networks that explain the data by codifying whole networks as solutions. However, in general, these models are slow, not scalable to real sized networks (thousands of genes), or require many parameters, the knowledge from an specialist or a large number of samples to be feasible. On the other hand, Reinforcement Learning is an adaptable goal oriented approach that does not require large labeled datasets and many parameters; can give good quality solutions in a feasible execution time; and can work automatically for a long time without the need of a specialist. Therefore, here we propose a way to adapt Reinforcement Learning to the Gene Regulatory Networks inference domain in order to get networks with quality comparable to one achieved by exhaustive search, but in much smaller execution time. Our experimental evaluation shows that our proposal is promising in learning and successfully finding good solutions across different tasks automatically in a reasonable time. However, scalabilty to networks with thousands of genes remains as limitation of our RL approach due to excessive memory consuming, although we foresee some possible improvements that could deal with this limitation in future versions of our proposed method.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1722875 - DAVID CORREA MARTINS JUNIOR
Membro Titular - Examinador(a) Externo ao Programa - 1675615 - LUIZ CARLOS DA SILVA ROZANTE
Membro Titular - Examinador(a) Externo à Instituição - SERGIO NERY SIMÕES - IFES
Membro Suplente - Examinador(a) Externo à Instituição - FELIPE LENO DA SILVA