Banca de QUALIFICAÇÃO: ARYANE ALVES VIGATO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ARYANE ALVES VIGATO
DATA : 07/08/2019
HORA: 14:00
LOCAL: sala 304, 3º andar, Bloco B, Campus SA da Fundação Universidade Federal do ABC, localizada na Avenida dos Estados, 5001, Santa Terezinha, Santo André, SP
TÍTULO:

Organogels lecitin-poloxamer-based for skin delivery: development, ex vivo permeation profile and stratum corneum structural evaluation

PÁGINAS: 70
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
SUBÁREA: Farmacotecnia
RESUMO:

Topical and transdermal routes are important strategies for drug administration, since they are non-invasive, avoid first-pass biotransformation and enable the use of self-administered pharmaceutical forms, which improves patient compliance. However, the clinical efficacy of this type of administration depends on the drug physico-chemical and pharmacological properties, as well as its bioavailability at the site of action, which is limited by the low permeability of the stratum corneum. Organogels are semi-solid systems, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase. These gels have advantages over conventional systems (creams, ointments, hydrogels), such as modulation of the rate and time of permeation, as well as affinity for the site of administration, according to adjustments in their composition. In this context, lipid and poloxamer (PLs) organogels form a two-phase system which can be effectively used as skin delivery systems for hydrophilic and lipophilic drugs, favoring their permeation across the stratum corneum. In this way, this project proposes the development of a system for dual drug-release considering the application of curcuminoid derivatives, as antioxidant and anti-inflammatory drugs, and lidocaine, a local anesthetic, aiming a pharmacological synergistic effect for the treatment of topical lesions (surgical incisions, dermatological inflammatory processes such as atopic dermatitis, psoriasis). All formulations will be studied by physico-chemical techniques, drug permeation profile and the stratum corneum structural evaluation, as well as their therapeutic efficiency in post-surgical incision models of and leishmanicidal activity.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1696841 - LUCIANO PUZER
Membro Titular - Examinador(a) Externo ao Programa - 1982740 - GUSTAVO MORARI DO NASCIMENTO
Membro Titular - Examinador(a) Externo ao Programa - 1718113 - ANA PAULA ROMANI
Membro Suplente - Examinador(a) Interno ao Programa - 1672728 - ANA CAROLINA SANTOS DE SOUZA GALVAO
Membro Suplente - Examinador(a) Externo ao Programa - 1909951 - ARTUR FRANZ KEPPLER