Banca de DEFESA: HECTOR ALVES DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HECTOR ALVES DA SILVA
DATE: 07/07/2023
TIME: 14:00
LOCAL: sala 312-3
TITLE:

Molecular entities search and optimization with potential application in the treatment of SARS-CoV-2 infections 

based on evolutionary information of relevant viral targets.

PAGES: 130
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUBÁREA: Química de Macromoléculas
SPECIALTY: Proteínas
SUMMARY:

Through evolutionary and structural approaches, this project aims to integrate different bioinformatics techniques to elucidate key proteins responsible for the general pathogenic mechanisms of coronaviruses. The goal is to identify potential molecules that can reduce infection or alleviate symptoms caused by these viruses. Given the increasing availability of data in public databases due to the ongoing SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) pandemic, a search for viral protein structures will be conducted in these databases. Computational analysis of these structures will help infer relevant proteins involved in viral replication and infection mechanisms. Key regions in these proteins that allow binding and interaction with molecules will be identified. The project aims to uncover potential molecules that can inhibit the pathogenic mechanisms of coronaviruses. This study presents a comprehensive approach where the expected results can apply to the current situation and future Coronaviridae viruses.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1676356 - ANTONIO SERGIO KIMUS BRAZ
Membro Titular - Examinador(a) Externo ao Programa - 1544403 - MAURICIO DOMINGUES COUTINHO NETO
Membro Titular - Examinador(a) Externo ao Programa - 1909951 - ARTUR FRANZ KEPPLER
Membro Suplente - Examinador(a) Externo ao Programa - 3292123 - DANILO TRABUCO DO AMARAL
Membro Suplente - Examinador(a) Externo à Instituição - MILENA TREVISAN PELEGRINO - UFABC