Banca de QUALIFICAÇÃO: PAMELA PINHEIRO MARTINS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : PAMELA PINHEIRO MARTINS
DATE: 04/05/2023
TIME: 09:00
LOCAL: Sala 212 do Bloco Zeta do Campus de São Bernardo do Campo da Universidade Federal do ABC
TITLE:

EVALUATION OF THE INFLAMMATORY RESPONSE AND INTESTINAL CHANGES IN A MODEL OF NEONATAL ANOXIA COMBINED WITH PERINATAL INFLAMMATION DUE TO MATERNAL IMMUNE ACTIVATION

PAGES: 59
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
SPECIALTY: Neurofisiologia
SUMMARY:

Normal neurodevelopment is maintained at the maternal-fetal interface by a refined balance of physical, hormonal and immunological changes that occur throughout the gestational period so that the developing individual develops in a healthy way. Thus, the dynamics of these changes by the mother confer greater vulnerability to the risk of contracting infections that configure a picture of maternal immune activation (AIM). Additionally, gestational complications such as AIM are associated with premature birth, a condition that can be fatal for the neonate and contribute to the incidence of oxygen deprivation. Neonatal anoxia is considered a major public health problem worldwide because it brings permanent sequelae to survivors. Its occurrence triggers several biochemical cascades that lead to cell death in susceptible brain structures, such as the hippocampus and cerebral cortex. Among the neuronal disorders arising from oxygen deprivation, Autism Spectrum Disorder (ASD) has been correlated with this clinical complication. Together with anoxia, gestational infections that lead to perinatal inflammation by AIM are commonly observed, as previously mentioned, both insults being known as two-hit. In a rodent model, the combination of AIM, modulating the fetal immune system, and postnatal oxygen deprivation, lead to the development of autistic-like behavior. There are reports that both aggressive stimuli lead to systemic changes in the offspring, especially in the gastrointestinal tract, which may influence the functioning of the central nervous system (CNS) due to the dysfunctional intestinal barrier, contributing to increased inflammation. Currently, we found that the two-hit was capable of causing important alterations in the brain, such as cell death and increased microglial marking, but also in the intestine, such as the increase in Toll-like receptor 4 (TLR4), suggesting that understanding its role in the proposed model can contribute to the development of new studies based on this receptor as a therapeutic target.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1887027 - FERNANDO AUGUSTO DE OLIVEIRA RIBEIRO
Membro Titular - Examinador(a) Externo à Instituição - CRISTIANO MENDES DA SILVA - UNIFESP
Membro Titular - Examinador(a) Externo à Instituição - ALEXANDRE SALGADO BASSO - UNIFESP
Membro Suplente - Examinador(a) Externo ao Programa - 1669152 - DANIEL CARNEIRO CARRETTIERO