Banca de QUALIFICAÇÃO: CATIA MELO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : CATIA MELO
DATA : 24/09/2020
HORA: 14:00
LOCAL: modo remoto
TÍTULO:

Streptozotocin effects in Wistar rats submitted to maternal separation

PÁGINAS: 50
GRANDE ÁREA: Ciências Biológicas
ÁREA: Biologia Geral
RESUMO:

The Alzheimer´s disease (AD) is the most common dementia that affects the elderly, promoting cognitive impairment. A very common comorbidity is major depression, a serious mood disorder that is a major cause of disability worldwide. Body temperature (Tb) has to be altered in patients affected by AD, in addition to the correlation already observed between stressful events and major depression and changes in Tc. The general objective of the present work is to evaluate the effects of streptozotocin (STZ) on the Tc of adult male Wistar rats submitted to maternal separation (MS). The animals were submitted to MS from postnatal day 2 to 14, for 3 hours a day. Two months after birth, the animals were subjected to behavioral tests and, subsequently, to a surgical procedure for placement of a datalogger and intracerebroventricular (icv) injection of STZ, followed, after 30 days, by behavioral and thermoregulatory tests. Behavioral tests demonstrated that MS animals showed behaviors related to anxiety (less time spent in the open arms of the elevated plus maze and in the center of the open field) and depression (less motivation in the forced swimming test). In the Barnes maze, MS animals and animals treated with STZ, showed a compromised memory and learning (reduced search for the target hole). In the thermoregulatory tests, the animals treated with STZ in the control groups had lower Tc, while the STZ animals in the MS groups had higher Tc, when compared to controls treated with vehicle. The STZ-treated MS animals showed higher Tc compared to vehicle-treated animals when exposed to cold, but did not show differences in exposure to heat. In the temperature selection challenge, the animals treated with STZ remained in neutral temperature (26ºC) for longer, than in the cold temperature (18ºC). In conclusion, animals with symptoms similar to AD of sporadic origin and depression and anxiety have altered thermoregulatory profile. However, MS does not worsen the conditions of animals treated with STZ when compared to control.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1994696 - SILVIA HONDA TAKADA
Membro Titular - Examinador(a) Interno ao Programa - 1893240 - RAQUEL VECCHIO FORNARI
Membro Titular - Examinador(a) Externo à Instituição - NÚBIA MANTOVAN FARDIN
Membro Suplente - Examinador(a) Interno ao Programa - 1771857 - CARLOS ALBERTO DA SILVA
Membro Suplente - Examinador(a) Interno ao Programa - 1676320 - TATIANA LIMA FERREIRA