Banca de QUALIFICAÇÃO: ESTELA BRAGA NEPOMOCENO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ESTELA BRAGA NEPOMOCENO
DATA : 19/08/2019
HORA: 10:00
LOCAL: na Sala S17, Térreo, Bloco Delta, Campus SBC da Fundação Universidade Federal do ABC, localizada na Alameda da Universidade, s/n, Bairro Anchieta - São Bernardo do Campo, SP.
TÍTULO:

Involvement of the insula and medial prefrontal cortex during decision making tasks in rats

PÁGINAS: 84
GRANDE ÁREA: Outra
ÁREA: Multidisciplinar
RESUMO:

There has been a growing interest in the insula in recent years as recent evidence suggests its involvement in high-order processes, such as detecting salient events to guide goal-directed behavior in decision-making tasks. Projections between the insula and medial prefrontal cortex (mPFC) - observed both in rats and humans - also suggest a function for the insula in the integration of autonomic responses with ongoing behavior and emotion. Although studies in humans and nonhuman animals have tried to describe the role of those structures in decision making tasks, their findings are not uniform and a possible causal relationship between those areas, as well as the description of their functional interaction, is still unclear. Given those projections, this research proposal aims to explore the role of the insula and mPFC in decision-making in rats during a gambling task involving uncertainty and delay. Specifically, we will assess the effects of bilateral pharmacological inactivations of the insula or mPFC (Experiment I); ipsilateral or contralateral pharmacological inactivation of the insula and CPFm (Experiment II); and the ipsilateral or contralateral pharmacological inactivation of the insula and single-unit recordings of neural activity in mPFC, and vice versa (Experiment III). The results of this project have relevance in the understanding of the neural mechanisms involved in encoding of uncertainty of reinforcement.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1955999 - ANDRE MASCIOLI CRAVO
Membro Titular - Examinador(a) Interno ao Programa - 1872537 - MARCELA BERMUDEZ ECHEVERRY
Membro Titular - Examinador(a) Externo à Instituição - MIRIAM GARCIA MIJARES - USP
Membro Suplente - Examinador(a) Interno ao Programa - 1893240 - RAQUEL VECCHIO FORNARI
Membro Suplente - Examinador(a) Externo à Instituição - KARINA POSSA ABRAHÃO - UNIFESP