Banca de DEFESA: NATÁLIA DE JESUS CONTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : NATÁLIA DE JESUS CONTO
DATE: 05/02/2024
TIME: 14:00
LOCAL: https://conferenciaweb.rnp.br/ufabc/defesa-mestrado-natalia
TITLE:

Glucose deficiency and its relationship with energy substrates in neuronal viability

PAGES: 60
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
SPECIALTY: Neurofisiologia
SUMMARY:

The dysregulation of glucose homeostasis in the brain has been associated with neurodegenerative processes. Reducing the supply of glucose to neurons can compromise its function and / or predispose the cell to death. Previous laboratory results show that neurons die when kept at 2.5mM glycemia, which in the literature is described as our physiological condition of glucose in the central nervous system (CNS). In this sense, these results suggest that neurons have additional energy support to the CNS. Thus, astrocytes, which are known to transport lactate to neurons, appear as a candidate for this important energy supply, making neurons not only dependent on extracellular glucose. Based on what was described above, the present study aims to investigate the neuronal dependence of these substrates (glucose and lactate) and to investigate the role of the astrocyte as a supplier of these energetic substrates.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1887027 - FERNANDO AUGUSTO DE OLIVEIRA RIBEIRO
Membro Titular - Examinador(a) Interno ao Programa - 1994696 - SILVIA HONDA TAKADA
Membro Titular - Examinador(a) Externo à Instituição - APARECIDA EMIKO HIRATA - UNIFESP
Membro Suplente - Examinador(a) Interno ao Programa - 1872537 - MARCELA BERMUDEZ ECHEVERRY
Membro Suplente - Examinador(a) Externo à Instituição - MANOEL DE ARCISIO MIRANDA FILHO - UNIFESP