Banca de QUALIFICAÇÃO: RAFAEL JARDIM DUARTE MOREIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : RAFAEL JARDIM DUARTE MOREIRA
DATE: 31/08/2023
TIME: 14:00
LOCAL: virtual
TITLE:

Noninvasive neuromodulation in chronic pain evidence-based umbrella review and efficacy of an accelerated protocol

PAGES: 32
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Treating chronic pain (DC) is a challenge for healthcare professionals and public decision-makers. In Brazil and worldwide, the prevalence of CP is approximately 30% of the population. The treatments used involve medication, surgical procedures, rehabilitation, and psychotherapy; however, a significant proportion of these individuals do not experience improvement in their clinical condition. In recent years, non-invasive brain neuromodulation (NIBS) has emerged as another treatment alternative for CP. This doctoral thesis consists of two studies whose main objective is to investigate the efficacy of non-invasive neuromodulation in treating chronic pain, through an approach composed of an umbrella review and a clinical trial project. In the first study, we conducted an umbrella review to synthesize and evaluate the results of multiple meta-analyses. The combined analysis of the results from these meta-analyses provides an overall and up-to-date view of the effectiveness of different NIBS techniques in reducing chronic pain under various clinical conditions. In the second study, we proposed a clinical trial with the aim of verifying the efficacy of a treatment protocol with four sessions of accelerated rTMS in controlling CP. Additionally, we will conduct an exploratory study of different EEG oscillations pre and post-treatment with rTMS-TB and investigate whether these characteristics predict the success of the intervention. This will be a crossover, randomized, and blind clinical trial. Individuals with musculoskeletal CP will be recruited and randomized into two groups, active rTMS-TB, and sham rTMS-TB. Clinical measurements related to pain, quality of life, and the presence of anxiety and depression will be taken, as well as pain threshold by pressure, and data on frequency band density with EEG will be collected. Additionally, connectivity measures will be performed through recorded EEG activity. Follow-up will be conducted after 24 and 48 hours of each intervention. It is expected that active rTMS-TB will be more effective than sham rTMS-TB in pain control, and there will be an increase in Alpha density associated with a reduction in pain intensity. Integrating the results from the umbrella review and the clinical trial will provide a comprehensive and updated perspective on the efficacy of non-invasive neuromodulation in treating chronic pain. This thesis is expected to significantly contribute to advancing scientific knowledge in chronic pain and aid in public health decision-making.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 1640243 - ALEXANDRE HIDEKI OKANO
Membro Titular - Examinador(a) Interno ao Programa - 2139904 - CLAUDINEI EDUARDO BIAZOLI JUNIOR
Membro Titular - Examinador(a) Externo à Instituição - ROGÉRIO ADAS AYRES DE OLIVEIRA
Membro Suplente - Examinador(a) Interno ao Programa - 1674604 - YOSSI ZANA