Banca de DEFESA: HÉLIO SANTOS ALVES DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HÉLIO SANTOS ALVES DA SILVA
DATE: 13/12/2022
TIME: 14:00
LOCAL: Sala S17 do Bloco Delta do Campus de São Bernardo do Campo da Universidade Federal do ABC
TITLE:

Learning and memory: interrelationships between calcium dynamics and energy metabolism

PAGES: 65
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
SPECIALTY: Neurofisiologia
SUMMARY:

Ca²⁺ is the main intracellular second messenger; its multivalence gives the cell the ability to coordinate a series of small and/or large-scale, and sometimes ambiguous, physiological processes such as cell death or proliferation. Thus, evolutionarily and due to its importance in intracellular signaling, it caused the emergence of a series of mechanisms and protein machinery to precisely control its quantity and dynamics in cells. Among all cells, neurons present an enormous range of processes mediated by Ca²⁺, such as: gene transcription, transmission and synaptic plasticity, changes in plasma membrane permeability, etc. There is an enormous protein apparatus to control the influx, release and removal of this ion from the intracellular medium. Furthermore, due to its versatility and universality, it is assumed that this ion is involved in a series of cognitive processes, such as memory and learning, and nevertheless plays a crucial role in the cellular mechanisms that govern these processes. The framework of studies on learning and memory has demonstrated the intricate management of the use of Ca²⁺ by the nervous system in the mechanisms of synaptic plasticity, intrinsic neuronal properties and energy metabolism alterations that influence the learning and memory process, emphasizing that modulations or failures in the signaling of the Ca²⁺ signaling cause cognitive changes. Therefore, this work intends to present how the dynamics of Ca²⁺ homeostasis and its deregulation would be correlated to different cellular mechanisms of learning and memory. Finally, throughout the text, observations and suggestions on a series of problems are made based on the analysis of several studies. One of them proposes a model of energetic coupling that encompasses not only the known astrocyte-neuron relationship (ANLS), but also between cell cytoplasm and synaptic transmission. Thus, evidencing Ca²⁺ as a central element of the biology of the nervous system, acting as an internal signaling molecule and consequent production of energy to carry out the activities of neurons.

BANKING MEMBERS:
Presidente - Interno ao Programa - 1887027 - FERNANDO AUGUSTO DE OLIVEIRA RIBEIRO
Membro Titular - Examinador(a) Interno ao Programa - 1994696 - SILVIA HONDA TAKADA
Membro Titular - Examinador(a) Externo à Instituição - MANOEL DE ARCISIO MIRANDA FILHO - UNIFESP
Membro Suplente - Examinador(a) Interno ao Programa - 1872537 - MARCELA BERMUDEZ ECHEVERRY
Membro Suplente - Examinador(a) Externo à Instituição - DANILO ROMAN CAMPOS - UNIFESP