Banca de QUALIFICAÇÃO: NATÁLIA DE JESUS CONTO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : NATÁLIA DE JESUS CONTO
DATE: 26/10/2022
TIME: 14:00
LOCAL: Sala 207 do Bloco Zeta do Campus de São Bernardo do Campo da Universidade Federal do ABC
TITLE:

Glucose deficiency and its relationship with energy substrates in neuronal viability

PAGES: 60
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
SPECIALTY: Neurofisiologia
SUMMARY:

The dysregulation of glucose homeostasis in the brain has been associated with neurodegenerative processes. Reducing the supply of glucose to neurons can compromise its function and / or predispose the cell to death. Previous laboratory results show that neurons die when kept at 2.5mM glycemia, which in the literature is described as our physiological condition of glucose in the central nervous system (CNS). In this sense, these results suggest that neurons have additional energy support to the CNS. Thus, astrocytes, which are known to transport lactate to neurons, appear as a candidate for this important energy supply, making neurons not only dependent on extracellular glucose. Based on what was described above, the present study aims to investigate the neuronal dependence of these substrates (glucose, lactate and pyruvate) and to investigate the role of the astrocyte as a supplier of these energetic substrates.

BANKING MEMBERS:
Presidente - Interno ao Programa - 1994696 - SILVIA HONDA TAKADA
Membro Titular - Examinador(a) Externo ao Programa - 1227329 - CESAR AUGUSTO JOAO RIBEIRO
Membro Titular - Examinador(a) Externo à Instituição - APARECIDA EMIKO HIRATA
Membro Suplente - Examinador(a) Interno ao Programa - 1676367 - ALEXANDRE HIROAKI KIHARA
Membro Suplente - Examinador(a) Interno ao Programa - 1872537 - MARCELA BERMUDEZ ECHEVERRY