Banca de QUALIFICAÇÃO: ALESSANDRA APARECIDA MARQUES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ALESSANDRA APARECIDA MARQUES
DATA : 20/09/2022
HORA: 09:00
LOCAL: Sala 205 do Bloco Zeta do Campus de São Bernardo do Campo da Universidade Federal do ABC
TÍTULO:

Relationship between behavioral parameters and the expression of glucose transporters, L-type Calcium-channels and plasma membrane Calcium-ATPase in a model of schizophrenia.

PÁGINAS: 65
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
ESPECIALIDADE: Neurofisiologia
RESUMO:

Schizophrenia is a chronic and highly disabling psychiatric disorder. The etiology of this disease is complex and still unknown; in this sense, disorders in glutamatergic neurotransmission due to hypofunction of the NMDA receptor (N-methyl-D-aspartate) have been proposed as one of the causes of the pathophysiology of the disease. The administration of ketamine, an NMDA receptor antagonist, emerges as an animal model of schizophrenia. Nevertheless, bioenergetic abnormalities and alterations in cellular calcium homeostasis have also been reported in the brain of schizophrenic patients. From this perspective, a direct link between signs and symptoms and total levels of voltage-activated Ca2+ channels, plasma membrane Ca2+-ATPase and glucose transporters in pathology has not yet been described. Aiming to investigate this relationship, this project will focus on developing a pharmacological paradigm of schizophrenia as a predictive model for the study of the hippocampal expression of GLUT1, GLUT3, Cav1.2, Ca2+-ATPase and its relationship with the negative, positive and cognitive symptoms characteristic of schizophrenia.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1994696 - SILVIA HONDA TAKADA
Membro Titular - Examinador(a) Interno ao Programa - 1676274 - CRISTIANE OTERO REIS SALUM
Membro Titular - Examinador(a) Interno ao Programa - 1893240 - RAQUEL VECCHIO FORNARI
Membro Suplente - Examinador(a) Interno ao Programa - 1675707 - FULVIO RIELI MENDES
Membro Suplente - Examinador(a) Interno ao Programa - 1872537 - MARCELA BERMUDEZ ECHEVERRY