Banca de QUALIFICAÇÃO: VICTOR RICARDO CANDIDO TORRES DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : VICTOR RICARDO CANDIDO TORRES DA SILVA
DATA : 23/08/2022
HORA: 14:00
LOCAL: https://conferenciaweb.rnp.br/webconf/carlos-177
TÍTULO:

Study on the distribution of FOSB and nNOs proteins after metoclopramide-induced oromandibular dyskinesia in C57Bl/6 mice

PÁGINAS: 30
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
RESUMO:

The study of the nitrergic system in the side effects caused by the blockade of the dopamine D2 receptor, such as catalepsy and tardive dyskinesia, has been explored by our group in Swiss mice. Understanding a little better the interaction of the nitrergic system with the dopaminergic system leads us to think that there must be a target molecule, such as the DARPP-32 protein in medium-sized spinous neurons in the striatum, which regulates the information sent by the striatum-nigral and striatum-pallidal efferences, involved in hyperkinetic/dyskinetic or akinetic effects, respectively. In the present study we intend to study the immunoreactivity of FosB, nNOS, GFAP proteins in the cingular cortex, striatum and substantia nigra, after induction of tardive dyskinesia with metoclopramide (Plasil®) in C57Bl/6 mice. We also intend to describe and correlate with the behavior the astrocytic activation that occurs through its participation in the synapses of this region. In the first phase, with behavior, it was demonstrated that Metoclopramide caused motor disorders of hypokinesia, such as catalepsy, and hyperkinesia, such as Vacuous Chewing Movement (VCM), at both doses 5-> 25 and 8mg/kg when compared to the group control. For the continuation of the study, it is necessary to complete the immunoreactivity evaluations of the proposed markers.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1994696 - SILVIA HONDA TAKADA
Membro Titular - Examinador(a) Interno ao Programa - 1893240 - RAQUEL VECCHIO FORNARI
Membro Titular - Examinador(a) Externo à Instituição - NÚBIA MANTOVAN FARDIN - UNIP
Membro Suplente - Examinador(a) Interno ao Programa - 1887027 - FERNANDO AUGUSTO DE OLIVEIRA RIBEIRO
Membro Suplente - Examinador(a) Interno ao Programa - 1675707 - FULVIO RIELI MENDES
Membro Suplente - Examinador(a) Externo à Instituição - GUILHERME SHIGUETO VILAR HIGA - USP