Banca de QUALIFICAÇÃO: VITOR DA SILVEIRA ALVES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : VITOR DA SILVEIRA ALVES
DATA : 03/08/2022
HORA: 14:00
LOCAL: Campus São Bernardo do Campo
TÍTULO:

Cellular energy sources for the removal of cytoplasmic calcium in neurons and its modulation by the transport of glucose from the plasma membrane

PÁGINAS: 65
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
ESPECIALIDADE: Neurofisiologia
RESUMO:

Alzheimer's disease (AD) is a neurogenerative disorder characterized by the formation of β-amyloid peptide (Aβ) plaques and neurofibrillary tangles (EN). Several studies point to the Aβ peptide as the primary cause of the disease. However, a long-time is observed between the abnormal production of Aβ peptide and the decline in cognitive functions common to Alzheimer's disease. Thus, the determination of the molecular mechanisms that delineate the asymptomatic phase of the disease is required for a better understanding of the pathophysiology of Alzheimer's disease, as well as for the proposition of new pharmacological targets. Changes in neuronal energy metabolism have been observed during the development of AD, indicating a potential target of study. In fact, the imbalance of energy metabolism is associated with several deleterious effects, among them is the impairment in the removal of cytosolic Ca2+. Restoration of the basal level of intracellular Ca2+ occurs through ATP-dependent mechanisms and is crucial for neuronal signaling pathways. Thus, in the absence of an adequate ATP supply, which comes mainly from two energetic pathways, glycolysis and mitochondria, the Ca2+ removal process is affected. However, it is not yet understood whether the change in Ca2+ signaling is the primary cause or a secondary factor of AD. Thus, we intend to clarify: (i) the individual contribution of the two main energetic pathways to cytosolic Ca2+ removal; (ii) the relationship between cytoplasmic glucose concentration and intracellular Ca2+.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1676367 - ALEXANDRE HIROAKI KIHARA
Membro Titular - Examinador(a) Externo ao Programa - 1544365 - GISELLE CERCHIARO
Membro Titular - Examinador(a) Externo à Instituição - KARINA RAMALHO BORTOLUCI - UNIFESP
Membro Suplente - Examinador(a) Interno ao Programa - 1994696 - SILVIA HONDA TAKADA
Membro Suplente - Examinador(a) Interno ao Programa - 1872537 - MARCELA BERMUDEZ ECHEVERRY
Membro Suplente - Examinador(a) Externo ao Programa - 1227329 - CESAR AUGUSTO JOAO RIBEIRO