Banca de QUALIFICAÇÃO: THIAGO TAKECHI OHNO BEZERRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : THIAGO TAKECHI OHNO BEZERRA
DATA : 09/08/2021
HORA: 15:00
LOCAL: UFABC - Campus São Bernardo do Campo (virtual)
TÍTULO:

Computational model for the simulation of prepulse inhibition test: interfaces with schizophrenia

PÁGINAS: 99
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
SUBÁREA: Neuropsicofarmacologia
RESUMO:

The acoustic startle response (ASR) is a reflex that is characterized by muscle contraction in response to a high intense sound. The ASR can be modulated by different mechanisms. One of them is the sensorimotor filter, that is a function of nervous system that prevent the interference in information processing by the motor response caused by other stimuli. In that sense, the prepulse inhibition test (PPI) is an operational measure of sensorimotor gating. The PPI is defined as the reduction in ASR in response to a salient stimulus when preceded in milliseconds by a low intensity stimulus that does not produce ASR. Several psychiatry disorders, and in particular schizophrenia, show deficits in PPI. In the present work we developed a neural network for the simulation of PPI. Here it was implemented modulatory units of PPI, as amygdala, nucleus accumbens, ventral pallidum and ventral tegmental area. The results showed that the model reproduce the main features of PPI observed in the animal experiments, like the effect of ISI and prepulse intensity variation. Furthermore, the simulation of GABAergic drugs in the modulatory units showed that amygdala hyperactivation, amygdala inhibition and ventral pallidum inhibition caused a decrease in PPI. Administration of dopaminergic agonists of D1, D2 and both receptors systemic, intra-amygdala and intra-nucleus accumbens also resulted in decrease of PPI. The opposite was observed by the administration of D2 receptor antagonist, it resulted in increase of PPI. These results are discussed taking as referential the dopaminergic hypothesis of schizophrenia and the functional alterations detected in amygdala and nucleus accumbens in schizophrenic patients.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1766041 - MARCELO BUSSOTTI REYES
Membro Titular - Examinador(a) Externo à Instituição - ANTÔNIO CARLOS ROQUE DA SILVA FILHO - USP
Membro Titular - Examinador(a) Externo à Instituição - VANESSA COSTHEK ABÍLIO
Membro Suplente - Examinador(a) Interno ao Programa - 1676320 - TATIANA LIMA FERREIRA