Banca de QUALIFICAÇÃO: MOISES DOS SANTOS CORREA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : MOISES DOS SANTOS CORREA
DATA : 08/02/2021
HORA: 13:00
LOCAL: por participação remota
TÍTULO:

Modulation of systems consolidation of contextual memories by activating or blocking glucocorticoid receptors after different training intensities of contextual fear conditioning

PÁGINAS: 90
GRANDE ÁREA: Ciências Humanas
ÁREA: Psicologia
SUBÁREA: Psicologia Fisiológica
ESPECIALIDADE: Psicobiologia
RESUMO:

Episodic memories are declarative memories, i.e. long-term memories, that can be accessed consciously and that have specific information about the space and time of the event that generated its acquisition. The study of episodic memory has enabled a better understanding of the phenomena that occur during its consolidation and retrieval, as well as its strength and specificity during the passage of time. These memories are modulated by the adrenal hormone Corticosterone (CORT). This modulation exerted by CORT is dependent on variables such as the intensity of the training and the plasma concentration of hormones during the window of synaptic consolidation of memory. Several studies suggest that both glucocorticoid receptors, both types I (Mineralocorticoid receptor, MR, of greater affinity with CORT) and type II (glucocorticoid receptor GR, of lower affinity with CORT) are related to the expression of spatial and contextual memory, but with different roles in this process. The GR are related with the early phases of the synaptic consolidation and are present in great density in hippocampus, amygdala and prefrontal cortex, areas associated with the acquisition, consolidation and retrieval of contextual memory. Different levels of CORT elicited by different training intensities cause different rates of memory generalization but the role played by GR on this phenomenon is still not well-understood. Therefore, it is important to investigate the effect of activation and selective blockade of these receptors. The results here reported indicate that stronger contextual fear conditioning trainings elicit higher activation of the anterior insular cortex during remote retrieval tests. Additionally, the post-training treatment with CORT modulates differentialy memory specificity in an intensity-dependent manner. We can conclude so far that modulation of the specificity of contextual memories by glucocorticoids is dependent on the levels of arousal elicited by the aversive situation.

MEMBROS DA BANCA:
Presidente - Interno ao Programa - 1762353 - MARIA CAMILA ALMEIDA
Membro Titular - Examinador(a) Externo à Instituição - JORGE ALBERTO QUILLFELDT - UFRGS
Membro Titular - Examinador(a) Externo à Instituição - CAROLINA DEMARCHI MUNHOZ - USP
Membro Suplente - Examinador(a) Interno ao Programa - 1954058 - MARCELO SALVADOR CAETANO