Screening of compounds with anti-cancer activitu produced by bacteria associated with marine sponges from the coast of São Paulo
Marine sponges are invertebrate animals that have a wide distribution and, therefore, occupy several oceanic regions. Currently, these are also considered holobiomes and, therefore, several researches have been developed with a focus on the complexity of the host, the symbionts and their relationships with each other. Furthermore, metagenomic studies have provided access to symbiont genes and the putative roles they play for host sponges. Thus, the present project gathers the partial results regarding the representativeness and bacterial diversity, isolated from the sponges Aplysina fulva and Aplysina caissara (endemic), collected in the coast of São Paulo State. It also presents the strains that amplified the genes of interest Polypeptides types I and II (PKS I and PKS II) and Non-Ribosomal Peptides (NRPS), known to be involved in the production of secondary metabolites and, of natural compounds of great biotechnological interest.