Banca de QUALIFICAÇÃO: WANDSON LUKAS DO NASCIMENTO AMORIM

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : WANDSON LUKAS DO NASCIMENTO AMORIM
Date: 20/07/2026
TIME: 14:00
LOCAL: Sala 306 do Bloco B do Campus de Santo André da Universidade Federal do ABC
TITLE:

Chemical characterization by molecular networking (GNPS) and evaluation of the antioxidant activity of hydroalcoholic extracts of ripe fruits of Solanum crinitum L. in non-cellular and cellular models[LA1]

PAGES: 38
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:

Solanum crinitum L. is a Brazilian Solanaceae species whose fruits remain largely unexplored regarding their chemical composition and biological properties. Here, we report the characterization of the major metabolites and antioxidant activity of hydroalcoholic extracts from the peel, pulp, and seeds of ripe S. crinitum fruits. Steroidal glycoalkaloids, mainly solasonine isomers, and phenolamides derived from caffeic, ferulic, and p-coumaric acids were identified as the predominant metabolites. All extracts scavenged reactive oxygen and nitrogen species (ROS and RNS, respectively), inhibited the oxidative burst of human neutrophils, and protected human erythrocytes against oxidative damage. The peel extract consistently exhibited the highest activity, which was associated with its higher content of catechol-containing phenolamides. These results indicate that ripe S. crinitum L. fruits are a promising source of bioactive compounds with antioxidant and cytoprotective properties.

COMMITTEE MEMBERS:
Presidente - Interno ao Programa - 3050857 - CELIO FERNANDO FIGUEIREDO ANGOLINI
Membro Titular - Examinador(a) Interno ao Programa - 1766090 - MIRELA INES DE SAIRRE
Membro Titular - Examinador(a) Externo ao Programa - 2353139 - ELOAH RABELLO SUAREZ
Membro Suplente - Examinador(a) Interno ao Programa - 3008569 - BRUNO GUZZO DA SILVA